BacEffluxPred: A two-tier system to predict and categorize bacterial efflux mediated antibiotic resistance proteins

Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants

Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels. In addition, most, if not all, strains of a given bacterial species present the same chromosomally-encoded efflux pumps. Altogether this indicates that multid...

Modelling proteins’ hidden conformations to predict antibiotic resistance

TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify hidden conformations and explore their role in determining TEM's specificity. We integrate these models with existing drug-design tools to create a...

antibiotic prescription and bacterial resistance

Efflux-mediated antimicrobial resistance.

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease. And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of reduced biocide susceptibility are common and the history of antibiotic resistance should not be ignored in the development and use of biocidal agents. Efflux mechanisms of resistance, both drug specific and multidru...

Bacterial antibiotic resistance pdf

Two page summaries of cross-cutting and bacteriaspecific antibiotic resistance topics. The first section provides context and an overview of antibiotic resistance.Antimicrobial resistance: global report on surveillance. Resistance to antibacterial drugs in selected bacteria of international concern. Previously harmful agents that is known today as antimicrobial resistance. Currently antimicrobi...